目的：
类风湿关节炎患者因潜在的传统危险因素（例如胰岛素抵抗）和炎症性疾病状态的协同作用，导致心血管疾病风险增加。本研究的目的在于评价类风湿关节炎患者炎症指标与胰岛素敏感性的相关性。
方法：
共纳入40例非糖尿病的类风湿关节炎患者 (19例男性)。所有患者均接受人体测量，实验室评估和口服葡萄糖耐量试验（OGTT）。使用由Matsuda等人提出的公式，根据在OGTT试验中获得的葡萄糖和胰岛素的动态值计算胰岛素敏感性指数（ISI）。
结果：
在单变量分析中，胰岛素敏感性指数与年龄、BMI、腰围、动脉收缩压、ESR、CRP和补体C3负相关，但与病程，动脉舒张压及补体C4无关。在非肥胖患者（BMI
结论：
不管是肥胖还是非肥胖的类风湿关节炎患者，补体C3水平均与胰岛素敏感性强相关。
附原文：
Abstract: OBJECTIVES: Rheumatoid arthritis (RA) is characterised by an excess of cardiovascular diseases (CVD) risk, attributable to a synergy between under-diagnosed traditional risk factors (i.e. insulin resistance) and inflammatory disease activity. The aim of the present study was to evaluate the correlation between inflammatory measures and insulin sensitivity in RA patients.
METHODS: Forty non-diabetic RA patients (19 males) were recruited. All patients underwent anthropometric measurements, laboratory evaluation and oral glucose tolerance test (OGTT). Insulin sensitivity index (ISI) was calculated with the equation proposed by Matsuda et al., from dynamic values of glucose and insulin obtained during OGTT.
RESULTS: In the univariate analysis, lnISI correlated inversely with age, BMI, waist circumference, sBP, ESR, lnCRP and complement C3, but not with disease duration, dBP or complement C4. In non-obese patients (BMI
目的：
类风湿关节炎患者因潜在的传统危险因素（例如胰岛素抵抗）和炎症性疾病状态的协同作用，导致心血管疾病风险增加。本研究的目的在于评价类风湿关节炎患者炎症指标与胰岛素敏感性的相关性。
方法：
共纳入40例非糖尿病的类风湿关节炎患者 (19例男性)。所有患者均接受人体测量，实验室评估和口服葡萄糖耐量试验（OGTT）。使用由Matsuda等人提出的公式，根据在OGTT试验中获得的葡萄糖和胰岛素的动态值计算胰岛素敏感性指数（ISI）。
结果：
在单变量分析中，胰岛素敏感性指数与年龄、BMI、腰围、动脉收缩压、ESR、CRP和补体C3负相关，但与病程，动脉舒张压及补体C4无关。在非肥胖患者（BMI
结论：
不管是肥胖还是非肥胖的类风湿关节炎患者，补体C3水平均与胰岛素敏感性强相关。
附原文：
Abstract: OBJECTIVES: Rheumatoid arthritis (RA) is characterised by an excess of cardiovascular diseases (CVD) risk, attributable to a synergy between under-diagnosed traditional risk factors (i.e. insulin resistance) and inflammatory disease activity. The aim of the present study was to evaluate the correlation between inflammatory measures and insulin sensitivity in RA patients.
METHODS: Forty non-diabetic RA patients (19 males) were recruited. All patients underwent anthropometric measurements, laboratory evaluation and oral glucose tolerance test (OGTT). Insulin sensitivity index (ISI) was calculated with the equation proposed by Matsuda et al., from dynamic values of glucose and insulin obtained during OGTT.
RESULTS: In the univariate analysis, lnISI correlated inversely with age, BMI, waist circumference, sBP, ESR, lnCRP and complement C3, but not with disease duration, dBP or complement C4. In non-obese patients (BMI