不要小看内源性呼气末正压（auto-PEEP）
原作者： Haney Mallemat，肖锋译 发布日期：2013-03-28
Title: Don't Fall Asleep on Auto-PEEP
题目：不要小看内源性呼气末正压（auto－PEEP）
Author 作者: Haney Mallemat
Mechanically ventilated patients can develop a condition in which air becomes trapped within the alveoli at end-expiration; this is called auto-PEEP.
机械通气的病人会造成肺泡气体在呼气末压的储留，这一现象称为内源性呼气末正压。
Auto-peep has several adverse effects:
内源性呼气末正压有几个副作用：
Barotrauma from positive pressure trapped within the alveoli
由肺泡内产生的正压力造成的压力损伤
Increased work of breathing
增加呼吸负荷
Worsening pulmonary gas exchange
肺气体交换阻力的增加
Hemodynamic compromise secondary to increased intra-thoraic pressure
由胸内压的增加所造成的血液动力学紊乱
Auto-PEEP classically occurs in intubated patients with asthma or emphysema, but it may also occur in the absence of such disease. The risk of auto-PEEP is increased in patients with:
内源性呼气末正压通常在机械通气的哮喘或肺气肿病人中发生，但没有这些情况时也会出现。内源性呼气末正压产生的危险与下列因素有关：
Short expiration times (i.e., inadequate time for the evacuation of alveolar air at end-expiration)
呼气时间短，没有足够的时间将呼吸末期肺泡内气体清除
Bronchoconstriction 支气管痉挛
Plugging of the bronchi (e.g., mucus or foreign body) creating a one-way valve and air-trapping
支气管栓子形成（如粘液或异物），导致单项版模，气体滞留
Auto-PEEP may be treated by:
内源性呼气末正压的治疗办法：
Reducing tidal volume 降低潮气量
Reducing the respiratory rate 减少呼吸频率
Decreasing inspiratory time 缩短吸气时间
Increasing PEEP 增加PEEP
Patients may need to be heavily sedated to accomplish the above ventilator maneuvers.
为达到如上的指标，可能需要对病人进行深度镇静。
不要小看内源性呼气末正压（auto-PEEP）
原作者： Haney Mallemat，肖锋译 发布日期：2013-03-28
Title: Don't Fall Asleep on Auto-PEEP
题目：不要小看内源性呼气末正压（auto－PEEP）
Author 作者: Haney Mallemat
Mechanically ventilated patients can develop a condition in which air becomes trapped within the alveoli at end-expiration; this is called auto-PEEP.
机械通气的病人会造成肺泡气体在呼气末压的储留，这一现象称为内源性呼气末正压。
Auto-peep has several adverse effects:
内源性呼气末正压有几个副作用：
Barotrauma from positive pressure trapped within the alveoli
由肺泡内产生的正压力造成的压力损伤
Increased work of breathing
增加呼吸负荷
Worsening pulmonary gas exchange
肺气体交换阻力的增加
Hemodynamic compromise secondary to increased intra-thoraic pressure
由胸内压的增加所造成的血液动力学紊乱
Auto-PEEP classically occurs in intubated patients with asthma or emphysema, but it may also occur in the absence of such disease. The risk of auto-PEEP is increased in patients with:
内源性呼气末正压通常在机械通气的哮喘或肺气肿病人中发生，但没有这些情况时也会出现。内源性呼气末正压产生的危险与下列因素有关：
Short expiration times (i.e., inadequate time for the evacuation of alveolar air at end-expiration)
呼气时间短，没有足够的时间将呼吸末期肺泡内气体清除
Bronchoconstriction 支气管痉挛
Plugging of the bronchi (e.g., mucus or foreign body) creating a one-way valve and air-trapping
支气管栓子形成（如粘液或异物），导致单项版模，气体滞留
Auto-PEEP may be treated by:
内源性呼气末正压的治疗办法：
Reducing tidal volume 降低潮气量
Reducing the respiratory rate 减少呼吸频率
Decreasing inspiratory time 缩短吸气时间
Increasing PEEP 增加PEEP
Patients may need to be heavily sedated to accomplish the above ventilator maneuvers.
为达到如上的指标，可能需要对病人进行深度镇静。